My 2000 Honda Accord overheated recently?

So my car recently overheated and now when I go to turn it on it runs fine for about a minute then it starts running really rough and there's random cylinder misfires. What could it be? Is it that my head gasket is blown? Any help is appreciated!

It could be. Take the radiator cap off and see if you get a Geyser. Go have a block test done if you have any questions.