How reliable are honda civic's?

I have a 2001 honda civic ex with 160,000 miles what should I worry about replacing like timing belts, oil change, tune up etc… It's a 4 cylinder vtec Single over head cam

The 2001 is an extremely good quality and reliable automobile, it should last many more miles if properly serviced and maintained. Like any other vehicle that has 160k miles, service for the timing belt, water pump, tires, brakes, belts, hoses, etc., should be properly maintained.

Your own experience shows they are very reliable if properly maintained. Timing belts on Honda vehicles should be replaced about every 60K miles. Have other belts, fluids, spark plugs, etc. Checked regularly.