Why is my 2005 Honda Civic EX shuddering/jerking when accelerating (mostly uphill)?

I'm currently having an issue with my 05 Honda Civic EX where my car seems to shudder/jerk (as if the car hesitates to accelerate) from 2nd gear and above between 2000-4000rpms. The check engine light is on and I've checked the codes with the OB2 Scanner and they result with P0300-P0304 (engine misfires). So I've changed the spark plugs and engine coils, but the problem still occurs. The drive has me a bit worried since the check engine light would flash on and off for a few seconds then stay on, rarely. Any suggestions or help would be gladly appreciated.

1. Cheap or contaminated/adulterated Gasoline
2. Dirty Injectors.
3. Faulty sensors, or computer.

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