My engine makes a weird noise sometimes when I drive?

I have 2008 Honda Odyssey DX. When I'm driving, there's no problem up until I drive up a slight hill. There's a cranking/grinding sound ONLY when I press the gas and I'm driving up a small hill. It stays for about 5 seconds and then it goes away. Any idea to what it could be?

Have a mechanic or someone mechanically inclined (no pun intended) test drive your car. That's pretty much the only way you'll get an idea of what's going on.

Pre ignition, or knocking. Caused by the fuel mixture firing before the piston reaches TDC. You need a tune-up (timing checked) or perhaps new spark plugs. If the news is the worst it could be worn timing gears or chain. It should have some attention from a qualified mechanic.