Are these speakers compatable?

I'm going to be getting new speakers for my car. I will be replacing my 6 1/2 and my 6 x 9s in my '99 Honda Accord LX. I have found these speakers:
6 1/2 Kickers (40CS654): http://www.crutchfield.com/p_2064CS654/Kicker-40CS654.html?tp=95
6 x 9 Kickers (41DSC6934): http://www.crutchfield.com/p_20641D6934/Kicker-41DSC6934.html?i=20641D6934&tp=64038#customer-reviews-tab

Now this is my very first time buying speakers. I will be running these speakers along side a Sony MEX-N5000BT stereo. I was about to purchase all three items when i realized, that the 6 1/2 speakers are 2-way speakers, and that the 6 x 9 speakers are 3-way. My question is, will these two be able to interact without an issue? Or will i need to adjust one or the other? Please let me know, and keep in mind this is my first time dealing with and modifying my car speakers so use words that a non-audiophile can understand.

Yes, they're fine.
The two critical specifications are impedance and power handling.
how many "ways" a speaker has isn't a factor.

There are 2-ways, 3-ways, 4-ways and more.
A "way" refers to a single sound producing element.
2-ways consist of a woofer and tweeter. 3-ways have a woofer, mid, tweeter or woofer, tweeter, "super"-tweeter. 4+ ways just add more tweeters.

All it takes is a good woofer and tweeter to produce exceptional sound.
Anything more than 3-way is just a gimmick to try to sell speakers.