Cars needs to have the key turned twice to start?

Takes two tries to start after sitting but only when i have less than 1/2 a tank old Honda New fuel filter new spark plugs battery and alternater also starter is fine what could it be? Fuel pump or is it a fuel leak?

Hi there's a lot more wrong with it than what you seem to think. It needs looking at by a honda dealer as a diagnostics check would reveal most of it's issues.

I think the tire pressure is low on the right rear tyre.

It sounds like a fuel pressure issue. You Really need a professional diagnosis. I can guarantee you would not need to turn the key twice is you held it in the start position longer.