2002 Honda Civic radiator/coolant problems?

It overheats when driven for moderate periods of time (30-45mins), and coolant leaks out with no traces. Even if not driven that long there's still always a hissing or bubbling coming from the coolant reservoir. I've changed the thermostat, water pump, and fixed to cooling fans and I tried to pressure test the system but the air is escaping from under the plastic cap of the reservoir.

Sounds like a leaking radiator cap to me your pressure tester may have an attachment to test the cap, try that. There's a pressure rating on the cap and you may also be able to see if the rubber seal on the bottom of the cap is torn or missing.