Moving to Tennessee from Miami, what should I know?

My girlfriend and I are moving to Knoxville Tennessee from Miami, fl. We're planning the trip for February, we will be 21. Our Main Reason is for cheap living, school and just getting away. It will be the first time we move out of our parents home. We already looked into U-Haul, we're going with the 5x9 trailer. We're gonna be using my 97 Honda Civic, gonna need to install a tow hitch as well. We're planning on only bringing her queen bed and mattress set with our 150cc scooter along with two 40 gallon tanks from our bearded dragons. That's all that's going in the trailer if more room is available were putting boxes of clothes. In my trunk I'm putting in boxes of clothes whatever it can fit really. If necessary I could tie something to the roof of my car. In my backseat is going be our two Dogs and front seat is us two. We're gonna make a few stops along the way to let the car cool off and eat, restroom etc.
I wanted to know things like:
What should I be expecting along the way?
What kind of weather conditions will I be faced with? Were planning to leave in the morning.
What would be the best method for driving there?
Where should be the best place to live in Knoxville?
What kind of major State Laws should I know about?
any other information on the state is appreciated! Even if it's just resident humor or habits or funny words to know. Like there's no lunch just dinner and super lol.

One of the best sources for a traveler to find out most suitable travel related information is: http://www.tripadvisor.com

You have to connect and talk with many experienced people from there and they will suggest you right tips to be used while you travel through the places.

Hope it helps you have a great experience.